11# Indication Mechanism of Action Database
22A database of paths that represent the mechanism of action from a drug to a disease in an indication.
33
4- > [ ** Database of mechanism of action paths for selected drug-disease indications** ] ( https://zenodo.org/record/3515487 )
4+ > [ ** Database of mechanism of action paths for selected drug-disease indications** ] ( https://zenodo.org/record/3516335 )
55 <br> <Small >Mayers, Michael; Steinecke, Dylan; Su, Andrew I.<small ><br >
66
7-
8- [ ![ DOI] ( https://zenodo.org/badge/DOI/10.5281/zenodo.3515518.svg )] ( https://doi.org/10.5281/zenodo.3515518 )
9-
7+ [ ![ DOI] ( https://zenodo.org/badge/DOI/10.5281/zenodo.3516335.svg )] ( https://doi.org/10.5281/zenodo.3516335 )
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119## Purpose
1210
@@ -17,13 +15,13 @@ as a path through a network of biomedical entities.
1715
1816## Curation
1917
20- Indications were selected at random from the set contained within DrugCentral. Half were taken from the full set,
18+ Indications were selected at random from the set contained within DrugCentral. Half were taken from the full set,
2119representing a set of common drug disease pairs, and the other half were selected from a pool of less-common diseases
22- to vary the targets and diseases treated.
20+ to vary the targets and diseases treated.
2321
24- Paths were derived from free-text descriptions found on DrugBank, Wikipeida and within literature. Concepts within the
22+ Paths were derived from free-text descriptions found on DrugBank, Wikipeida and within literature. Concepts within the
2523text were then normalized to a concept type (Drug, Protein, Pathway, etc) and relationships between the concepts were
26- determined from the source. Finally concepts were mapped to an identifier depending on the concept type according to
24+ determined from the source. Finally concepts were mapped to an identifier depending on the concept type according to
2725the following table:
2826
2927| Concept Type | Identifier Source|
@@ -38,7 +36,7 @@ the following table:
3836| Drug | MESH, DrugBank |
3937| Molecular Function | GO |
4038| Pathway | REACT |
41- | Phenotype | HP |
39+ | Phenotype | HP |
4240| Protein | UniProt |
4341| Protein Family | InterPro |
4442| Taxon | NCBITaxon |
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