diff --git a/src-tauri/src/proxy/forwarder.rs b/src-tauri/src/proxy/forwarder.rs
index 635a8bc32..1919ffe8f 100644
--- a/src-tauri/src/proxy/forwarder.rs
+++ b/src-tauri/src/proxy/forwarder.rs
@@ -939,6 +939,10 @@ impl RequestForwarder {
             .parse::<http::Uri>()
             .ok()
             .and_then(|u| u.authority().map(|a| a.to_string()));
+        let apply_openrouter_codex_header_guard =
+            should_guard_openrouter_codex_headers(adapter.name(), &base_url, &effective_endpoint);
+        let connection_header_tokens =
+            apply_openrouter_codex_header_guard.then(|| collect_connection_header_tokens(headers));
 
         // 预计算 anthropic-beta 值（仅 Claude）
         let anthropic_beta_value = if adapter.name() == "Claude" {
@@ -1016,6 +1020,13 @@ impl RequestForwarder {
                 continue;
             }
 
+            // --- OpenRouter chat/responses 专用：补充剥离 hop-by-hop 请求头 ---
+            if let Some(connection_header_tokens) = connection_header_tokens.as_ref() {
+                if should_strip_openrouter_codex_request_header(key_str, connection_header_tokens) {
+                    continue;
+                }
+            }
+
             // --- 认证类 — 用 adapter 提供的认证头替换（在原始位置） ---
             if key_str.eq_ignore_ascii_case("authorization")
                 || key_str.eq_ignore_ascii_case("x-api-key")
@@ -1318,6 +1329,61 @@ fn is_bedrock_provider(provider: &Provider) -> bool {
         .unwrap_or(false)
 }
 
+const OPENROUTER_CODEX_HOP_BY_HOP_REQUEST_HEADERS: &[&str] = &[
+    "connection",
+    "keep-alive",
+    "proxy-authenticate",
+    "proxy-authorization",
+    "proxy-connection",
+    "te",
+    "trailer",
+    "trailers",
+    "upgrade",
+];
+
+fn should_guard_openrouter_codex_headers(
+    adapter_name: &str,
+    base_url: &str,
+    endpoint: &str,
+) -> bool {
+    if adapter_name != "Codex" || !base_url.contains("openrouter.ai") {
+        return false;
+    }
+
+    let path = endpoint
+        .split_once('?')
+        .map(|(path, _)| path)
+        .unwrap_or(endpoint);
+
+    matches!(
+        path,
+        "/chat/completions" | "/responses" | "/responses/compact"
+    )
+}
+
+fn collect_connection_header_tokens(
+    headers: &axum::http::HeaderMap,
+) -> std::collections::HashSet<String> {
+    headers
+        .get_all("connection")
+        .iter()
+        .filter_map(|value| value.to_str().ok())
+        .flat_map(|value| value.split(','))
+        .map(str::trim)
+        .filter(|name| !name.is_empty())
+        .map(|name| name.to_ascii_lowercase())
+        .collect()
+}
+
+fn should_strip_openrouter_codex_request_header(
+    key_str: &str,
+    connection_header_tokens: &std::collections::HashSet<String>,
+) -> bool {
+    let lower_key = key_str.to_ascii_lowercase();
+    OPENROUTER_CODEX_HOP_BY_HOP_REQUEST_HEADERS.contains(&lower_key.as_str())
+        || connection_header_tokens.contains(lower_key.as_str())
+}
+
 fn build_retryable_failure_log(
     provider_name: &str,
     attempted_providers: usize,
@@ -1700,6 +1766,73 @@ mod tests {
         ));
     }
 
+    #[test]
+    fn collect_connection_header_tokens_tracks_dynamic_hop_by_hop_headers() {
+        let mut headers = HeaderMap::new();
+        headers.insert(
+            "connection",
+            HeaderValue::from_static("keep-alive, x-custom-hop, Upgrade"),
+        );
+
+        let tokens = collect_connection_header_tokens(&headers);
+
+        assert!(tokens.contains("keep-alive"));
+        assert!(tokens.contains("x-custom-hop"));
+        assert!(tokens.contains("upgrade"));
+    }
+
+    #[test]
+    fn should_guard_openrouter_codex_headers_only_for_openrouter_chat_and_responses() {
+        assert!(should_guard_openrouter_codex_headers(
+            "Codex",
+            "https://openrouter.ai/api/v1",
+            "/chat/completions"
+        ));
+        assert!(should_guard_openrouter_codex_headers(
+            "Codex",
+            "https://openrouter.ai/api/v1",
+            "/responses?stream=true"
+        ));
+        assert!(should_guard_openrouter_codex_headers(
+            "Codex",
+            "https://openrouter.ai/api/v1",
+            "/responses/compact"
+        ));
+        assert!(!should_guard_openrouter_codex_headers(
+            "Claude",
+            "https://openrouter.ai/api",
+            "/v1/messages"
+        ));
+        assert!(!should_guard_openrouter_codex_headers(
+            "Codex",
+            "https://api.openai.com/v1",
+            "/responses"
+        ));
+    }
+
+    #[test]
+    fn should_strip_openrouter_codex_request_header_covers_static_and_dynamic_hop_by_hop_headers() {
+        let mut connection_tokens = std::collections::HashSet::new();
+        connection_tokens.insert("x-custom-hop".to_string());
+
+        assert!(should_strip_openrouter_codex_request_header(
+            "connection",
+            &connection_tokens
+        ));
+        assert!(should_strip_openrouter_codex_request_header(
+            "proxy-connection",
+            &connection_tokens
+        ));
+        assert!(should_strip_openrouter_codex_request_header(
+            "x-custom-hop",
+            &connection_tokens
+        ));
+        assert!(!should_strip_openrouter_codex_request_header(
+            "anthropic-version",
+            &connection_tokens
+        ));
+    }
+
     // ==================== Copilot 动态 endpoint 路由相关测试 ====================
 
     /// 验证 is_copilot 检测逻辑：通过 provider_type 判断