Hi,
The append function has been deprecated in more recent versions of pandas, leading to an error when running gcsc.
It might be worth adding a conda environment or list of required packages to run gcsc.
For example, this conda .yaml seems to works fine:
name: gcsc
channels:
- bioconda
- conda-forge
- defaults
dependencies:
- python=3.8
- pandas=1.4.0
- scipy
- numpy