v0.1.0 — Initial Research Release

PY-BRAIN v0.1.0 — Initial Research Release

About

PY-BRAIN is a brain tumor MRI segmentation pipeline with epistemic uncertainty
quantification, Platt calibration, and multi-model ensemble fusion. Designed for
reproducible research in medical imaging.

What's New

• Initial release with SegResNet + TTA-4 ensemble
• MC-Dropout uncertainty estimation (15 samples)
• Platt calibration per subregion (WT/TC/ET)
• STAPLE ensemble (implemented, pending validation)
• Comprehensive validation on BraTS2021 cases

Active Models

Model	Weight	Status
SegResNet	0.60	Active
TTA-4	0.40	Active
MC-Dropout	—	Active
Platt Calibration	—	Active
SwinUNETR	0.00	Disabled (pending validation)
nnU-Net	0.00	Disabled (no pretrained weights)

Validation Results (BraTS2021)

• Dice WT: 0.933 | Dice TC: 0.905 | Dice ET: 0.925 | HD95: 10.3mm

⚠️ Research Use Only

This software is NOT a certified medical device. See SECURITY.md for disclaimers.

Citation

See CITATION.cff or use the "Cite this repository" button on GitHub.

DOI

DOI will be assigned by Zenodo upon release publication.

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