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gtollefson/README.md

George A. Tollefson

PhD Candidate in Pathobiology at Brown University | Bioinformatics Data Analyst & Developer

I am a bioinformatics data analyst and developer with 9 years of experience spanning published research software development and genomics sequence analysis pipelines. My expertise bridges high-throughput multiomics data generation, tool development, and analysis with a deep expertise in human and eukaryotic infectious pathogen biology.

Currently, I am a 4th-year doctoral candidate in Dr. Jeff Bailey's Lab at Brown University, where I study the genetic architecture of drug-resistant malaria parasites in East Africa. I focus on developing high throughput genomics sequencing assays with accompanying custom, user-friendly, automated sequence analysis pipelines and data science tools to support global surveillance and combat antimalarial resistance.


Research & Focus Areas

  • Genomic Epidemiology: Investigating Plasmodium falciparum genetic variation and the emergence of frontline artemisinin resistance.
  • Pipeline Development: Building robust, scalable, and automated NGS data analysis pipelines for high-performance computing (HPC) environments.
  • Tool Development: Creating intuitive, open-source bioinformatics software in Julia, R, and Python to make complex genomic visualization and analysis accessible to global research teams.

Technical Toolkit

Category Technologies & Tools
Languages Python, R, Julia, Bash / Unix Shell, Snakemake, Nextflow
Bioinformatics NGS Alignment, Variant Calling (GATK, BWA, Samtools), Population Genetics
Data Science & Dev Git / GitHub, High-Performance Computing (HPC), Data Visualization

Core Projects & Affiliations


Connect with Me

“Passionate about applying advancements in data science and bioinformatics to solve complex biomedical challenges and improve health outcomes.”

Pinned Loading

  1. compbiocore/VariantVisualization.jl compbiocore/VariantVisualization.jl Public

    Julia package powering VIVA, our tool for visualization of genomic variation data. Manual:

    Julia 90 13

  2. alperuzun/Proteinarium alperuzun/Proteinarium Public

    Java 6

  3. TranslationalBioinformaticsLab/INDELfindR TranslationalBioinformaticsLab/INDELfindR Public

    INDELfindR is an command line tool for detecting complex insertions and deletions (indels) from indexed BAM files.

    R 3

  4. bailey-lab/miplicorn bailey-lab/miplicorn Public

    A unified framework for molecular inversion probe and amplicon analysis. Provides the tools to parse, manipulate, analyze, and visualize data.

    R 4 2

  5. bailey-lab/nano_mamp_pipes bailey-lab/nano_mamp_pipes Public

    NanoMAMP Pipes is a free-to-use one-step automated pipeline designed for comprehensive analysis of molecular inversion probe and amplicon sequencing data from Nanopore platforms.

    Shell

  6. George-Tollefson-Bioinformatics/gt_omics_analysis_toolkit George-Tollefson-Bioinformatics/gt_omics_analysis_toolkit Public

    A growing collection of custom executables for bioinformatics analysis

    R