Brain Age Prediction using Stacking Ensemble

MRI-based brain age estimation using region-wise stacking ensemble method.

📊 Results

• Baseline (Regional Mean GMV): MAE = 6.83 years, r = 0.853
• Stacking Ensemble (L0+L1): MAE = 5.73 years, r = 0.899
• Improvement: 16.1% (1.10 years MAE reduction)

🧠 Methods

• Dataset: IXI (N=563)
• Atlases: Schaefer-800 + Brainnetome-36 + Cerebellar-34
• Models: ElasticNet (Level-0 + Level-1)

📁 Files

• Brain Age Estimation Using IXI Data.ipynb - Complete analysis pipeline
• summary_figure.png - Main results visualization
• model_comparison.png - Baseline vs SE comparison
• error_analysis.png - Error distribution & residuals
• region_importance.png - Top predictive brain regions
• final_results_table.csv - Performance metrics

📚 Reference

Based on: Georgios Antonopoulos , Shammi More , Simon B. Eickhoff , Federico Raimondo , Kaustubh R. Patil , for the Alzheimer's Disease Neuroimaging Initiative 1 (2025) "Region-wise stacking ensembles for estimating brain-age using structural MRI"

🎓 Author

Fatma Karateke