This repository contains the code for bioinformatics analyses to analyze RNA-seq data and systematically compare mouse transcriptomics data to human disease signatures from the Accelerating Medicines Partnership in Alzheimer’s Disease (AMP-AD) studies (Wan et al., 2020)[https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2021.713726/full#B81].
As a case study, we utilized RNA-seq expression data from the 5xFAD mouse model, as described in the publication titled "Comprehensive Evaluation of the 5XFAD Mouse Model for Preclinical Testing Applications: A MODEL-AD Study" (https://pubmed.ncbi.nlm.nih.gov/34366832/).
Requires:
- R
- SynapseR
- Bioconductor packages
Make sure R and the necessary Bioconductor packages are installed before running the pipeline.
Instructions for running the pipeline will be added here.
Contribution guidelines will be added here.
License information will be added here.